EMMPRIN in extracellular vesicles from peritoneal mesothelial cells stimulates the invasion activity of diffuse-type gastric cancer cells

Peritoneal metastasis of gastric cancer (GC) results in extremely poor prognoses. The peritoneal cavity is covered by a monolayer mesothelial cells (PMCs). Interactions between GC and PMCs might play pivotal role metastasis. Extracellular vesicles (EVs) correlate with intercellular communication. Although communication be associated the metastatic process, EVs from remains unclear. We investigated effects on cells. Three cell lines (OCUM-12, NUGC-3, MKN74) four were used. derived invasion migration evaluated Matrigel assay. Factors contained PMC analyzed; extra-cellular matrix metalloproteinase inducer (EMMPRIN) was detected EVs. an EMMPRIN inhibitor invasion-stimulating activity examined. expressions 110 GCs immunohistochemistry. significantly promoted diffuse-type cells, i.e., OCUM-12 NUGC-3 stimulated inhibited inhibitor. A high expression worse cancer-specific survival peritoneal-recurrence-free survival. stimulate malignant progression GC. useful prognostic marker recurrence patients.